Modelling the potential role of engineered symbiotic bacteria in malaria control

讲座时间 Datetime: 2021年6月3日 星期四，09:00-10:30
地点 Venue: 腾讯会议，743 460 346
报告人 Speaker:  邹幸福 教授
单位 Affiliation: 加拿大西安大略大学
报告摘要 Abstract:
A recent experimental study suggests that the engineered symbiotic bacteria Serratia AS1 may provide a novel, effective and sustainable biocontrol of malaria. These recombinant bacteria have been shown to be able to rapidly disseminate throughout mosquito populations and to effificiently inhibit development of malaria parasites in mosquitoes in controlled laboratory experiments. In this talk, I will report a recent work in which we develop a climate-based malaria model which involves both vertical and horizontal transmissions of the engineered Serratia AS1 bacteria in mosquito population. We show that the dynamics of the model system is totally determined by the vector reproduction ratio Rv, and the basic reproduction ratio R0. If Rv ≤ 1, then the mosquito-free state is globally attractive. If Rv > 1 and R0 ≤ 1, then the disease-free periodic solution is globally attractive. If Rv > 1 and R0 > 1, then the positive periodic solution is globally attractive. Numerically, we verify the obtained analytic result and evaluate the effects of releasing the engineered Serratia AS1 bacteria in fifield by conducting a case study for Douala, Cameroon. We fifind that ideally, by using Serratia AS1 alone, it takes at least 25 years to eliminate malaria from Douala. This implies that continued long term investment is needed in the fifight against malaria and confifirms the necessity of integrating multiple control measures. This is joint work with Dr. Xiunan Wang.